Aggressive brain cancer in adults and children is a devastating diagnosis most often leading to rapid death or severe disability. Although genetically heterogeneous, aggressive tumours share common metabolic traits that could be treatment targets including enhanced glycolytic activity (Warburg effect), which alters intracellular pH (pHi) homeostasis. In response, we have recently developed an in vivo pH mapping technique using high field 1H MRI, positioning our group to swiftly advance this treatment approach by rapidly evaluating the effect of pharmacologic acidification.

Including:

  • Ultra high field MR Spectroscopy

  • Diffusion Tensor Imaging

  • Chemical Exchange Saturation Transfer

Research in the Bartha lab at the Centre for Functional and Metabolic Mapping at Robarts Research Institute, Western University, is focused on the development of ultra high field MRI methods to monitor brain metabolism and function. Some more specific areas are listed below. Click each heading to learn more.

Including:

  • Alzheimers Disease

  • Spinal Cord Compression

  • Concussion

  • Epilepsy

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