Tissue pH in Brain Cancer

Applying magnetic field gradients in different directions during MR imaging of the brain can be utilized for measurements of the signal attenuation from water diffusion, which ultimately provides the diffusion maps of the water, more precisely magnitude, the degree of anisotropy, and the orientation of diffusion, within the cerebral tissue.

These diffusion maps bestow valuable and unique opportunity to assess white matter integrity and connectivity patterns in the brain which can be interestingly exploited for structural analysis of the brain under diverse normal and pathological circumstances, opening a novel emerging area in the field of neuroimaging called diffusion weighed imaging (DWI).

In our laboratory as part of our research collaborations with the Ontario Neurodegenerative Disease Research Initiative (ONDRI) (http://ondri.ca/), we are developing a comprehensive image analysis pipeline for multisite/multiscanner raw diffusion weighted data of the brain which can be utilized not only for denoising, outlier detection, and quality control procedures of the brain DWI data, but also for diverse processing tasks including voxel-based diffusion tensor fittings, scalar maps (such as Fractional Anisotropy, Mean Diffusivity, Relative Diffusivity maps) calculations and visualizations, and tract-based/region-based statistical analysis of the DWI data. Our ultimate goal in the brain DWI project is to improve sensitivity, objectivity, and interpretability of the multi-scanner/multi-site DWI studies of the brain rendering DWI as a reliable and applicable diagnostic practice in clinics.